Volume 12
www.preclina.com
Highest Medical Unmet Needs
Accelerating
Lupus Discovery
High quality full range service for lupus drug discovery
Optimized Efficacy
Evaluation Platform
Reliable Data for Your IND Submission
Preclina has launched the “PreVIVO™” service, designed to
maximize cost-efficiency and shorten development timelines.

Accelerated
Turnaround Time

Cost-
Efficiency

Modular
Platform

Tailored
Study Design

Bridging the Translational Gap
in Lupus Drug Discovery
From Novel Therapeutics to Standard of Care
Major Drug Target with Utmost
Medical Unmet Needs
Heterogeneity & Complexity:

High patient variability and multi-organ
involvement (skin, kidney, CNS) complicate
clinical trial designs.

Limitations of Current SOC:

Despite advances, long-term remission
remains elusive, demanding novel
MOA-based therapies.

Critical Quality Gap in Preclinical Data:

Inadequate scientific rigor in reproducibility
and precision directly escalates
the risk of late-stage clinical attrition.

Strategic Study Design
for IND Success

Target-Specific Model Selection: Guidance on choosing MRL/Faslpr vs NZW/B F1 based on your MOA.

Customized Endpoints: Beyond survival—incorporating diverse biomarkers & pathology scoring.

Translational Intelligence
& Risk Mitigation

Bridging Data Gaps: Correlating preclinical efficacy with potential clinical outcomes.

Go/No-Go Decision Support: Objective data analysis to de-risk your pipeline before IND.

Strategic Lupus Model Portfolio
Aligning Drug MOA with Disease Pathogenesis

MRL/Faslpr
Lupus Model

Rapid Efficacy Screening:
Aggressive T cell driven
onset enabling accelerated
Go/No-Go decision making.
 

Multi-organ involvement:
including massive
lymphadenopathy and
cutaneous lesions.

NZW/B F1
Lupus Model

Chronic Disease
Evaluation:Gold standard
for assessing long-term
survival and chronic lupus
nephritis progression.

Clinically relevant renal
failure: Driven by chronic
autoantibody-mediated
immune complex deposition.

Optimized Model Selection

We offer distinct murine models optimized for your
candidate’s specific immunological target and study timeline.

Multidimensional Profiling
From Clinical Phenotypes to Molecular Mechanisms
Holistic Disease Assessment
Simultaneous evaluation of phenotype & mechanism.
Reducing pipeline lead time through integrated analysis
Standardized Readouts

Clinical: Body weight, Skin score, Proteinuria

Immunological: Autoantibody (anti-dsDNA), FACS analysis

Pathological: Glomerulonephritis & Interstitial scoring

Primary Endpoints (Phenotype)

Integrated Endpoints : Clinical and pathological measures
capturing both renal function and tissue-level disease changes,
serving as the primary indicators of therapeutic efficacy

Key Functional Readout :Quantitative assessment of
roteinuria supported by renal histopathological evaluation

Precision Renal Pathology &
Automated Digital Quantification
Precision Scoring of Glomerular &
Tubulointerstitial Lesions
Quantitative Morphometry for IND-Ready Data: Assessing
glomerular cellularity, crescent formation, and immune
complex deposition.

Ensuring Data Integrity through Objective Evaluation and
Rigorous Pathological Review.
Reproducible Scoring System:
Validated protocols to eliminate inter-observer
bias and ensure reproducibility.
High-Throughput Digital Reporting:
Automated scanning and AI-driven analysis for
rapid, scalable data delivery.
Tailored IHC & Analytical Solutions:
Differentiated service offerings specifically
designed to validate unique drug MOAs.
Mechanistic Insight &
Advanced MOA Profiling
Mechanistic
Insight (MOA):
 
Elucidating
Target-Specific
immune modulation
pathways.
 
Essential for
Go/No-Go
Decision-making

Bridging mouse
efficacy to human
clinical endpoints

Regulatory
Data Package:
 
Supporting IND
filing and providing
data readiness for LO.
 
 
Accelerate drug development and
secure critical clues for MOA elucidation.

Through in-depth analysis of anti-dsDNA antibodies, C4 concentrations,
and flow cytometry, Preclina enables detailed tracking of therapeutic response
and data-driven development decisions.

Unlock validated analytical insights with Preclina and drive your project forward
with precision.

Strategic Partnership for
Accelerated Lupus Drug Discovery
Accelerating Discovery with an Integrated PreVIVO™ Platform
Minimizing Lead Optimization Time & Maximizing Success Rates.