Precilina - Accelerating Lupus Discovery

Volume 12 www.preclina.com

Optimized Efficacy
Evaluation Platform

Reliable Data for Your IND Approval

Preclina has launched the “PreVIVO™” service, designed to
maximize cost-efficiency and shorten development timelines.

Accelerated
Turnaround Time

Cost-
Efficiency

Modular
Platform

Tailored
Study Design

Bridging the Translational Gap
in Lupus Drug Discovery

From Novel Therapeutics to Standard of Care

Major Drug Target with Utmost
Medical Unmet Needs

Heterogeneity & Complexity:

High patient variability and multi-organ involvement (skin, kidney, CNS) complicate clinical trial designs.

Limitations of Current SOC:

Despite advances, long-term remission remains elusive, demanding novel MOA-based therapies.

Critical Quality Gap in Preclinical Data:

Inadequate scientific rigor in reproducibility and predictive clinical translation undermines the value of large animal critical data.

Strategic Study Design
for IND Success

Translational Intelligence
& Risk Mitigation

Target-Specific Model Selection:Guidance on choosing MRL/Fas^lpr vs NZW/B F1 based on your MOA.

Customized Endpoints: Beyond survival—incorporating diverse biomarkers & pathology scoring.

Bridging Data Gaps:Correlating preclinical efficacy with potential clinical outcomes.

Go/No-Go Decision Support:Objective data analysis to de-risk your pipeline before IND.

Strategic Lupus Model Portfolio

Aligning Drug MOA with Disease Pathogenesis

MRL/Fas^lpr
Lupus Model

NZW/B F1
Lupus Model

Rapid Efficacy Screening: Aggressive T cell driven
onset enabling accelerated
Go/No-Go decision making.

Multi-organ involvement: including massive
lymphadenopathy and
cutaneous lesions.

Chronic Disease
Evaluation: Gold standard
for assessing long-term
survival and chronic lupus
nephritis progression.

Clinically relevant renal
failure: Driven by chronic
autoantibody-mediated
immune complex deposition.

Multidimensional Profiling

From Clinical Phenotypes to Molecular Mechanisms

Holistic Disease Assessment

Simultaneous evaluation of phenotype & mechanism.
Reducing pipeline lead time through integrated analysis

Standardized Readouts

Clinical: Body weight, Skin score, Proteinuria

Immunological: Autoantibody (anti-dsDNA), FACS analysis

Pathological: Glomerulonephritis & Interstitial scoring

Precision Renal Pathology &
Automated Digital Quantification

Precision Scoring of Glomerular &
Tubulointerstitial Lesions

Quantitative Morphometry for IND-Ready Data: Assessing glomerular cellularity, crescent formation, and immune complex deposition.

Ensuring Data Integrity through Objective Evaluation and Rigorous Pathological Review.

Mechanistic Insight &
Advanced MOA Profiling

Mechanistic
Insight (MOA):

Elucidating Target-Specific immune modulation pathways

Essential for
Go/No-Go
Decision-making

Bridging murine efficacy to human clinical endpoints

Regulatory
Data Package

Supporting IND filing and providing data readiness for LO

Accelerate drug development and
secure critical clues for MOA elucidation.

Through in-depth analysis of anti-dsDNA antibodies, C4 concentrations,
and flow cytometry, Preclina enables detailed tracking of therapeutic response
and data-driven development decisions.

Unlock validated analytical insights with Preclina and drive your project forward
with precision.